The Kass lab focuses on elucidating new mechanisms and treatments for cardiac hypertrophy and failure.
Basic science investigations span an array of inquiries, such as understanding the basic mechanisms underlying cardiac dyssynchrony and resynchronization in the failing heart, and beneficial influences of nitric oxide/cGMP/protein kinase G and cGMP-targeted phosphdiesterase signaling cascades on cardiac maladaptive stress remodeling. Recently, the latter has particularly focused on the role of phosphodiesterase type 5 and its pharmacologic inhibitors (e.g. sildenafi, Viagra®), on myocyte signaling cascades modulated by protein kinase G, and on the nitric oxide synthase dysregulation coupled with oxidant stress.
The lab also conducts clinical research and is presently exploring new treatments for heart failure with a preserved ejection fraction, studying ventricular-arterial interaction and its role in adverse heart-vessel coupling in left heart failure and pulmonary hypertension, and testing new drug, device, and cell therapies for heart disease. A major theme has been with the use of advanced non-invasive and invasive catheterization-based methods to assess cardiac mechanics in patients.
what's new?
Pacemaker Induced Transient Assynchrony (PITA) staves off Heart Failure | 12/23/2015Making hearts beat dyssynchronously for hours each day actually helps heart failure - See Why Continue reading...html_link recent publications
Transient Receptor Potential Channel 6 Regulates Abnormal Cardiac S-Nitrosylation in Duchenne Muscular Dystrophy | 2017Chung et al. | PNAS..html_link Cellular and Molecular Aspects of Dyssynchrony and Resynchronization | 2017Kirk and Kass | Heart Fail Clin...html_link html_linkCardiac Phosphodiesterases and Their Modulation for Treating Heart Disease | 2017Kim and Kass | Handbook of Experimental Pharmacology..html_link html_link