Active RO1HL119012 PKG Redox Modulation of Cardiac Function and Disease | 9/1/13-8/31/17NIH/NHLBIThis work explores the mechanisms and implications for oxidation modification of protein kinase G in the heart. New work shows this impacts its cardioprotective effects and the efficacy of various methods to stimulate it.
RO1 HL 114910 Mechanisms of Right Ventricular Dysfunction in PAH | 7/1/12-6/30/17NIH/NHLBIStudies the function of the right ventricle and its interaction with the pulmonary vascular circuit in patients with
HHSN268201000032C The Johns Hopkins Proteomic Innovation Center in Heart Failure | 08/15/10-08/14/15NIH/NHLBIThe goal is to develop and apply novel proteomic methods to answer clinical relevant questions in HF.
1P50HL084946 SCCOR: Molecular Determinants of Pulmonary Arterial Hypertension | 01/12/07-12/31/13NIH/NHLBIThis project is designed to examine the complex interplay between pulmonary vascular and RV remodeling as well as the increased morbidity and mortality in scleroderma-associated Pulmonary Arterial hypertension. We anticipate our work to provide the potential for meaningful translational research that will facilitate development of new strategies, uncover therapeutic targets, and define new biomarkers and prognostic indicators that will limit the current dismal outcome of PAH.
RO1 HL093432 Regulation and Function of cGMP-dependent Protein Kinase in Cardiac Hypertrophy | 04/01/09-03/31/14NIH/NHLBIThis is a new RO1 submission addressing mechanisms by which cyclic GMP dependent kinase (PKG) influence cardiac hypertrophy stress remodeling. Studies are performed at the molecular, cellular, and whole organ level to determine how PKG is regulated in cardiac myocyte, modulating downstream hypertrophy signaling and mitochondria biogenesis/function.
PO1 HL 59480 Cardiac Myosin Binding Protein-C: Structure, Function, and Regulation | 12/01/04-01/31/15University of Vermont/NIHThis multi-center PPG studies how myosin binding protein C functions in the sarcomere, and how post-translational modifications by phosphorylation influence this function. Core C focuses on in vivo heart mechanics can analysis.
1P01HL107153 Glycoconjugates and Cardiovascular Disease | 07/01/11-05/31/18NIH/NHLBIThe purpose of the Cardiac and Myocyte Physiology Core D is to provide required methods for thehtml_link
09 CVD 01 Redox and Nitrosative Regulation of Cardiac Remodeling: Novel Therapeutic Approaches for Heart Failure | 01/01/10-12/31/14Fondation Leducq Transatlantic NetworkThis multinational network of excellence focuses on how oxidative and nitrosative stress modifies critical proteins involved with myocardial function, growth, and cell survival, and plays a role in the pathophysiology of cardiac failure. Major goals are the elucidation of novel signaling pathways and overall hypothesis that highly targeted anti-oxidant therapies can be more effective in ameliorating heart disease than prior efforts using broad based anti-oxidant scavengers.
CT32 HL07227-32 Pathophysiology of Myocardial Disease | 07/01/11-06/30/16NIH/NHLBI
PO1 HL077180 Pathobiology of Cardiac Dyssynchrony & Resynchronization | 09/15/04-06/30/15NIH/NHLBIThis program project grant aims to elucidate basic molecular and cellular mechanisms underlying cardiac failure and dyssynchronous contraction, and identifying pathways targeted by cardiac resynchronization therapy that likely underlie its efficacy. Project 1 focuses on mechanisms of cardiac reserve in particular how CRT enhanced myofilament calcium sensitivity and also alters beta receptor signaling coupled to a loss of inhibitory G-protein coupling.

Pending Mid-Atlantic Heart Failure Network | 01/01/12-12/31/18University of Pennsylvania/NIHClinical Heart Failure Trial consortium between Johns Hopkins and University of Pennsylvania and Lancaster Medical Center. RFA for NIH-heart disease trial consortium.